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Related Concept Videos

X-ray Crystallography02:18

X-ray Crystallography

The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
Determination of Crystal Structures01:29

Determination of Crystal Structures

In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...
X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal crystal...

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Related Experiment Video

Updated: Jun 4, 2026

Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules
07:11

Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules

Published on: March 22, 2019

JBluIce-EPICS control system for macromolecular crystallography.

Sergey Stepanov1, Oleg Makarov, Mark Hilgart

  • 1GM/CA-CAT at the APS, Biosciences Division, Argonne National Laboratory, Argonne, Illinois 60439, USA. sstepanov@anl.gov

Acta Crystallographica. Section D, Biological Crystallography
|March 2, 2011
PubMed
Summary
This summary is machine-generated.

New JBluIce control systems enhance macromolecular crystallography experiments. This open-source software, developed for the Advanced Photon Source, streamlines operations for microcrystallography using EPICS and Java.

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Area of Science:

  • Structural Biology
  • Biophysics
  • Materials Science

Background:

  • Macromolecular crystallography beamlines at the Advanced Photon Source (APS) are in high demand.
  • Existing beamlines offer excellent beam quality and can analyze micro-sized crystals.
  • There is a need for advanced control systems to optimize beamline performance and accommodate new developments.

Purpose of the Study:

  • To develop a fast, intuitive, and robust control system for GM/CA-CAT beamlines.
  • To leverage existing technologies like EPICS and BluIce for enhanced functionality.
  • To facilitate crystallographic experiments, particularly those involving microcrystals.

Main Methods:

  • Integration of EPICS (Experimental Physics and Industrial Control System) for distributed hardware control.
  • Development of a Java-based graphical user interface (JBluIce) using Eclipse RCP.
  • Implementation of a plug-in architecture and unified motion controls for flexibility.

Main Results:

  • The JBluIce system offers a streamlined and expedited user experience.
  • Unified motion controls allow for on-the-fly scanning and optimization of beamline components.
  • The open-source nature facilitates wider adoption and further development.

Conclusions:

  • JBluIce provides a powerful, user-friendly control system for macromolecular crystallography.
  • The system is particularly beneficial for microcrystallography experiments.
  • This advancement enhances the capabilities of the GM/CA-CAT beamlines at APS.