[Encounter of cancer cells with bone. Cancer and inflammation--input and output of NF-κB - ]
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Updated: Jun 4, 2026

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
Published on: January 12, 2020
1Department of pharmacology, Tokyo Women's Medical University.
Abstract:
NF-κB activation is frequently found in a variety of tumors, especially in those that are resistant to chemotherapy. The malignant phenotypes of tumor cells that are required for invasion and metastasis could be established by the output of NF-κB signaling including interactions with white blood cells, anti-apoptosis and angiogenesis. Consequently, by utilizing the similar mechanisms for immune cells to migrate through the body, tumor cells migrate via blood stream, survive against selective pressures in other organs they stop by, achieve re-growth as metastasis, or make a clinical relapse by traveling back to the primary site.
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