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["Molecular-targeting prevention" of cancer. The theory and its possibilities]

Toshiyuki Sakai1

  • 1Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Japan. tsakai@koto.kpu-m.ac.jp

Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
|March 2, 2011
PubMed

Insights

Molecular-targeting prevention reactivates tumor suppressor genes like retinoblastoma (RB) and p53. Cancer-preventive foods enhance pathways like TRAIL-DR5, synergistically boosting apoptosis and cancer prevention.

Area of Science:

  • Oncology
  • Molecular Biology
  • Preventive Medicine

Context:

  • Traditional cancer prevention often lacks specific molecular targets.
  • Tumor suppressor genes, such as retinoblastoma (RB) and p53, are frequently inactivated in malignant tumors.

Purpose:

  • To introduce and explore the concept of "molecular-targeting prevention" for cancer.
  • To investigate the role of RB and p53 genes in cancer prevention strategies.
  • To examine the potential of food-derived factors in cancer prevention via gene regulation and apoptosis induction.

Summary:

  • Proposed "molecular-targeting prevention" strategy focusing on reactivating inactivated tumor suppressor genes (RB and/or p53).
  • Identified that "gene-regulating chemoprevention" using food factors can restore RB/p53 functions.
  • Introduced "combination-oriented molecular-targeting prevention" to synergistically enhance preventive effects.
  • Investigated the TNF-related apoptosis-inducing ligand (TRAIL)-death receptor 5 (DR5) pathway, finding food factors enhance it for synergistic cancer cell apoptosis.

Impact:

  • Suggests novel strategies for cancer prevention by targeting specific molecular pathways.
  • Highlights the potential of dietary components in cancer chemoprevention.
  • Aims to contribute to more effective cancer prevention through synergistic approaches.

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