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Production of IgG Fusion Proteins Transiently Expressed in Nicotiana benthamiana
Published on: January 16, 2021
Emerging antibody products and Nicotiana manufacturing
Kevin J Whaley1, Andrew Hiatt, Larry Zeitlin
1Mapp Biopharmaceutical, Inc., San Diego, CA, USA. kevin.whaley@mappbio.com
Abstract:
Antibody based products are not widely available to address multiple global health challenges due to high costs, limited manufacturing capacity, and long manufacturing lead times. Nicotiana-based manufacturing of antibody products may now begin to address these challenges as a result of revolutionary advances in transient expression and altered glycosylation pathways. This review provides examples of emerging antibody-based products (mucosal and systemic) that could be competitive and commercially viable when the attributes of Nicotiana-based manufacturing (large scale, versatile, rapid, low cost) are utilized.
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