Related Experiment Video
Updated: Jun 4, 2026
Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets
Published on: February 16, 2020
Towards xenotransplantation of pig islets in the clinic
1Living Cell Technologies Ltd, Auckland, New Zealand. belliott@lctglobal.com
Purpose Of Review:
Porcine islet xenotransplantation into humans faces two major hurdles - safety issues related to xenosis and xenorejection of the transplants. The former has been overcome mainly by selection of a suitable disease-free source herd.
Recent Findings:
Four strategies have been employed to date to overcome the rejection, all of which have shown some efficacy in animal models.
Summary:
Immune suppression, Sertoli cell co-transplantation and microencapsulation have been tried in type 1 diabetic humans with some clinical benefit derived reported from the latter two. Unaware hypoglycemia in particular seems amenable to the microencapsulation approach.
