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Updated: Jun 4, 2026

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

Microbial safety in xenotransplantation.

Nicolas J Mueller1, Yasuhiro Takeuchi, Giada Mattiuzzo

  • 1Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, Switzerland.

Current Opinion in Organ Transplantation
|March 2, 2011
PubMed
Summary

Microbial safety is crucial for pig-to-human xenotransplantation. Monitoring for viruses like herpesviruses and porcine endogenous retroviruses (PERV), alongside other pathogens, is essential for safe clinical trials.

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Area of Science:

  • Transplantation immunology
  • Infectious disease microbiology
  • Comparative virology

Background:

  • Porcine islet cell transplantation is advancing towards clinical trials.
  • Microbial safety is a primary concern in pig-to-human xenotransplantation.
  • Understanding viral and bacterial pathogen risks is critical.

Purpose of the Study:

  • To review recent progress in identifying and managing pathogens relevant to xenotransplantation.
  • To highlight key viruses such as herpesviruses and porcine endogenous retroviruses (PERV).
  • To address emerging pathogen concerns in xenotransplantation.

Main Methods:

  • Review of current literature on xenotransplantation pathogens.
  • Analysis of viral infectivity across species barriers.

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Preparation and Maintenance of Bioexclusion IsoPositive Cage Experiment for Human Fecal Transplantation into Germ-Free Mice
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Last Updated: Jun 4, 2026

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
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Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

Preparation and Maintenance of Bioexclusion IsoPositive Cage Experiment for Human Fecal Transplantation into Germ-Free Mice
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Preparation and Maintenance of Bioexclusion IsoPositive Cage Experiment for Human Fecal Transplantation into Germ-Free Mice

Published on: February 28, 2025

  • Assessment of genomic data for pathogen characterization.

    • Main Results:

    • Herpesvirus cross-species transmission potential is underestimated and requires donor/recipient monitoring.
    • Exclusion of donors and recipient monitoring for exogenous pathogens like Parvovirus-4 are necessary.
    • Swine genome data aids in selecting donors with lower PERV infectivity; rigorous PERV monitoring is vital.

    Conclusions:

    • Diverse pathogens (viral and bacterial) pose risks in xenotransplantation.
    • Prescreening of donor animals is paramount.
    • Careful patient monitoring and follow-up are essential for safety.