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Related Experiment Video

Updated: Jun 4, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

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Published on: August 6, 2021

Ocular straylight in albinism.

Bastiaan Kruijt¹, Luuk Franssen, Liesbeth J J M Prick

¹Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. b.kruijt@nin.knaw.nl

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|March 2, 2011

Summary

Iris print-contact lenses (CLs) can significantly reduce ocular straylight in albinism patients with high light transmission through the iris. This study quantifies straylight contributions and evaluates CL effectiveness in managing this visual impairment.

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Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Area of Science:

Ophthalmology
Genetics
Biophysics

Background:

Albinism is an inherited disorder impacting melanin production, leading to reduced pigment in the iris and fundus.
This pigment reduction increases light transmission and fundus reflection, contributing to ocular straylight.
Ocular straylight significantly impairs vision in individuals with albinism.

Purpose of the Study:

To investigate the contribution of iris transmission and fundus reflection to ocular straylight in albinism.
To evaluate the efficacy of iris print-contact lenses (CLs) in reducing ocular straylight.

Main Methods:

Quantified ocular straylight using the straylight parameter (s) in 17 albinism subjects.
Measured straylight as a function of angle and wavelength, with and without iris print-CLs.
Estimated individual contributions of light transmission and reflectance to straylight.

Main Results:

Straylight levels varied significantly, with reflectance contributing up to s=17 and transmission up to s=101 in some cases.
Iris print-CLs significantly reduced straylight in six subjects with high transmission-related straylight.
Eleven subjects showed no significant improvement, indicating low transmission-related straylight.

Conclusions:

Iris transmission is a significant contributor to ocular straylight in albinism.
Iris print-CLs offer a potential therapeutic benefit for albinism patients experiencing significant straylight due to iris transmission.
Understanding individual straylight components is crucial for predicting the effectiveness of iris print-CLs.