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Related Concept Videos

Tail-anchoring of Proteins in the ER Membrane01:45

Tail-anchoring of Proteins in the ER Membrane

Tail-anchored, or TA, proteins are estimated to make up to 3-5% of membrane proteins found in the eukaryotic cell. Such proteins have a single transmembrane domain located approximately 30 amino acid residues upstream from the C-terminal end. As a result, the signal recognition particle (SRP) cannot guide a TA protein to the ER membrane for cotranslational insertion. Hence, they are integrated into the ER membrane post-translationally using their C-terminal end as the anchor. TA proteins...
Hindsight Biases01:12

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Tip-of-the-Tongue Phenomenon01:10

Tip-of-the-Tongue Phenomenon

The tip-of-the-tongue (TOT) phenomenon is a cognitive experience characterized by a temporary inability to retrieve specific information from memory despite having a strong feeling of knowing the information. Although individuals cannot access the target word or detail, they frequently recall related elements, such as its initial letter, syllable count, or context. This partial retrieval often causes frustration, as one might recognize a familiar face or know that a name starts with a specific...
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Related Experiment Video

Updated: Jun 4, 2026

The Tail Suspension Test
10:17

The Tail Suspension Test

Published on: January 28, 2012

A tale of pseudo tail.

Kamal Hamoud1, Janan Abbas

  • 1Department of Orthopedic Surgery, Poria Medical Center, Tiberias, Israel. k_hamoud@yahoo.com

Spine
|March 2, 2011
PubMed
Summary

A symptomatic pseudo tail in a child, caused by coccygeal segmentation failure, was successfully treated with coccygectomy. Long-term follow-up showed regrowth of the coccyx in normal alignment, resolving the patient's symptoms.

Area of Science:

  • Pediatric Surgery
  • Congenital Malformations
  • Orthopedic Surgery

Background:

  • Caudal appendages, including true tails and pseudo tails, are rare congenital anomalies.
  • Pseudo tails are often caused by protruding coccygeal vertebrae and typically require surgical removal.
  • Segmentation failure of coccygeal vertebrae can lead to abnormal coccyx positioning.

Observation:

  • A 7-year-old girl presented with a symptomatic pseudo tail due to a lordotic coccyx deformity from partial segmentation.
  • The patient experienced discomfort and functional interference due to the coccygeal malformation.

Findings:

  • Surgical resection of the coccyx (coccygectomy) successfully resolved the patient's symptoms.
  • Eight years post-surgery, radiographic evaluation revealed regeneration of a small coccygeal bone in normal alignment.

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Related Experiment Videos

Last Updated: Jun 4, 2026

The Tail Suspension Test
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Published on: January 28, 2012

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04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

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07:26

Isolation of Genomic DNA from Mouse Tails

Published on: July 29, 2007

  • The regenerated coccyx did not cause recurrent symptoms or malalignment.
  • Implications:

    • Coccygectomy is an effective treatment for symptomatic pseudo tails caused by coccygeal malformations.
    • The coccyx has regenerative potential, with new bone formation possible after resection.
    • Understanding coccygeal development is crucial for managing these rare pediatric conditions.