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Relationship between pro-anti-inflammatory cytokines, T-cell activation and CA 125 in obese patients with heart
1Department of Biochemistry, Ain Shams University, Faculty of Pharmacy, Cairo, Egypt. adia_hamdy@hotmail.com
Insights
Carbohydrate antigen 125 (CA 125), a tumor marker, is elevated in heart failure (HF) patients and correlates with inflammatory cytokines and T-cell activation. This suggests CA 125 is linked to the cytokine system in HF.
Area of Science:
- Cardiology
- Immunology
- Oncology
Background:
- Elevated inflammatory cytokines are observed in cardiovascular disease (CVD).
- This study explores cytokine, T-cell activation marker, and CA 125 relationships in Egyptian heart failure (HF) patients.
Purpose of the Study:
- To investigate the relationship between pro-anti-inflammatory cytokines, T-cell activation marker, and CA 125 in obese Egyptian HF patients.
- To determine if CA 125 levels differ between obese and non-obese HF patients.
Main Methods:
- 60 HF patients and 30 controls (age 50-70) were studied.
- HF patients were categorized into non-obese mild HF (NYHA class I/II) and obese severe HF (NYHA class III/IV).
- Serum levels of TNF-α, IL-6, IL-10, sIL-2R/CD25, and CA 125 were measured using ELISA.
Main Results:
- HF patients exhibited significantly higher levels of TNF-α, IL-6, IL-10, sIL-2R/CD25, and CA 125 compared to controls.
- Obese HF patients showed significantly higher levels of these markers than non-obese HF patients.
- CA 125 positively correlated with BMI, TNF-α, IL-6, and sIL-2R/CD25 in HF patients.
Conclusions:
- CA 125 is markedly elevated in heart failure patients.
- CA 125 levels correlate with pro-inflammatory cytokines (TNF-α, IL-6) and T-cell activation marker (sIL-2R/CD25).
- The tumor marker CA 125 is closely associated with the cytokine system in heart failure.
Background:
This researcher previously found that serum levels of some inflammatory cytokines are elevated in patients with cardiovascular disease (CVD). Hence, this study investigated the relationship between circulating levels of pro-anti-inflammatory cytokines, T-cell activation marker and carbohydrate antigen 125 (CA 125) for the first time in obese Egyptian patients with heart failure (HF).
Material/Methods:
This study included 60 HF patients, and 30 normal controls, with age range 50-70 years. HF patients were divided into 2 groups: non-obese mild HF according to clinical status (New York Heart Association Class) (NYHA class I/II) (n = 20) and obese severe HF (NYHA class III/IV) (n = 40). Serum pro-anti-inflammatory cytokine levels (TNF-α, IL-6, and IL-10), T-cell activation marker (sIL-2R/CD25), and CA 125; tumor marker were measured by ELISA.
Results:
Serum levels of TNF-α, IL-6, and IL-10 as pro-anti-inflammatory cytokines, sIL-2R/CD25 as T-cell activation marker, and CA 125 as tumor marker were significantly higher in HF patients than in normal controls. Moreover, serum levels of TNF-α, IL-6, sIL-2R/CD25, and IL-10, as well as CA 125 were significantly higher in the obese than in the non-obese mild HF patients. Correlation analysis showed that CA 125 was positively related to BMI, TNF-α, IL-6, and sIL-2R/CD25 in the HF patients group.
Conclusions:
These findings show that CA 125 is markedly elevated in HF patients, and is correlated with serum TNF-α, IL-6, and sIL-2R/CD25 levels. Therefore, we can conclude that CA125, being a tumor marker, is closely related to the cytokine system.
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