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Related Experiment Video

Updated: Jun 4, 2026

Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
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Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography

Published on: August 11, 2023

CCR3 and choroidal neovascularization.

Yiwen Li1, Deqiang Huang, Xin Xia

  • 1Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

Plos One
|March 2, 2011
PubMed
Summary
This summary is machine-generated.

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CCR3 does not play a significant role in the development of wet age-related macular degeneration (AMD). Targeting VEGF-A and mTOR pathways remains a viable therapeutic strategy for suppressing choroidal neovascularization (CNV) in AMD.

Area of Science:

  • Ophthalmology
  • Immunology
  • Molecular Biology

Background:

  • Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the elderly.
  • Wet AMD involves choroidal neovascularization (CNV), leading to rapid central vision loss.
  • VEGF-A neutralization is the standard treatment for wet AMD, but CCR3's role is under investigation.

Purpose of the Study:

  • To investigate the role of CCR3 in the development of CNV.
  • To compare the efficacy of CCR3 targeting with VEGF-A targeting in suppressing CNV.
  • To evaluate the potential of CCR3 as a therapeutic target for wet AMD.

Main Methods:

  • Matrigel-induced CNV model in rats and mice.
  • Treatment with CCR3 antagonist (SB328437) and CCR3 neutralizing antibodies.

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Related Experiment Videos

Last Updated: Jun 4, 2026

Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
05:14

Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography

Published on: August 11, 2023

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09:56

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model

Published on: January 21, 2018

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Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

  • Assessment of CNV area and CCR3 expression via immunostaining.
  • Comparison with VEGF-A neutralizing antibodies and rapamycin (mTOR inhibitor).

    • Main Results:

    • CCR3 inhibition did not significantly alter CNV development in the models used.
    • No significant difference in CNV areas was observed between control and CCR3-targeted eyes.
    • VEGF-A neutralizing antibodies and rapamycin significantly suppressed CNV.
    • CCR3 showed no specific expression in or near CNV.

    Conclusions:

    • CCR3 does not appear to play a significant role in CNV development.
    • Targeting CCR3 may not be a therapeutically effective strategy for suppressing CNV.
    • VEGF-A and mTOR targeting strategies show continued promise for treating wet AMD.