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Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
Psuedomyxoma peritonei secondary to adenocarcinoma of the cecum
Hussah Al-Buainain1, Yasser Al-Jehani, Khaled Moghazy
1Department of Surgery, University of Dammam, Dammam, Kingdom of Saudi Arabia.
Abstract:
Pseudomyxoma peritonei is a rare progressive disease. Patients commonly present with a picture of acute appendicitis or with increasing abdominal girth. We present a case of a 71 year old man who presented with right iliac fossa pain, fever and vomiting. His abdominal examination revealed right iliac fossa mass which was confirmed radiologically. Diagnostic laparoscopy showed jelly like material along with a right iliac fossa mass. The aspirate was negative for malignancy initially. Due to persistance and progression of his disease he underwent right hemicolectomy. Histopathological diagnosis showed moderately differentiated adenocarcinoma of the cecum Duke's C2.
Insights
Pseudomyxoma peritonei, a rare condition, often mimics appendicitis. This case highlights a 71-year-old man with cecal adenocarcinoma presenting with pseudomyxoma peritonei symptoms.
Area of Science:
- Gastroenterology
- Oncology
- Surgical Pathology
Background:
- Pseudomyxoma peritonei (PMP) is a rare, progressive malignancy characterized by mucinous ascites.
- Patients frequently present with non-specific symptoms, including abdominal distension or acute appendicitis-like presentations.
Observation:
- A 71-year-old male presented with right iliac fossa pain, fever, and vomiting.
- Physical examination revealed a palpable right iliac fossa mass, further confirmed by radiological imaging.
- Diagnostic laparoscopy identified gelatinous material and a right iliac fossa mass, with initial aspirates negative for malignancy.
Findings:
- Despite initial negative cytology, persistent disease progression necessitated surgical intervention.
- A right hemicolectomy was performed due to the unrelenting nature of the condition.
- Histopathological analysis confirmed moderately differentiated adenocarcinoma of the cecum, Duke's C2 staging.
Implications:
- This case underscores the importance of considering PMP in the differential diagnosis of abdominal masses and appendicitis-like symptoms.
- Delayed diagnosis and treatment can occur, emphasizing the need for thorough investigation in persistent cases.
- Accurate histopathological diagnosis is crucial for appropriate staging and management of cecal adenocarcinoma presenting as PMP.
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