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[Maternal influence on susceptibility to cleft palate (1)]
H M Palomino1, M T Peredo, M A Montenegro
1Facultad de Odontologia, Universidad de Chile.
Revista De La Facultad De Odontologia (Santiago, Chile)
|January 1, 1990
Summary
Nonsteroidal anti-inflammatory drugs like Indomethacin can cause cleft palate in rat embryos. Maternal factors significantly influence this effect, highlighting a crucial maternal effect in drug-induced developmental abnormalities.
Area of Science:
- Developmental biology
- Pharmacology
- Teratology
Context:
- Palate fusion is a critical developmental process in embryonic development.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used medications.
- Genetic susceptibility to teratogens can vary between individuals and strains.
Purpose:
- To investigate the teratogenic effects of Indomethacin on palate fusion in rat embryos.
- To assess the influence of different rat strains with varying susceptibility on Indomethacin-induced cleft palate.
- To determine the role of maternal factors in the development of drug-induced cleft palate.
Summary:
- Indomethacin significantly inhibits palate fusion in a strain-dependent manner in rat embryos.
- Embryos from susceptible female rats showed a greater incidence of Indomethacin-induced cleft palate compared to those from resistant females.
- Reciprocal crosses indicated a significant maternal influence on the teratogenic effects of Indomethacin.
Impact:
- This study reveals a maternal effect in Indomethacin-induced cleft palate, crucial for understanding drug safety during pregnancy.
- Findings contribute to knowledge of the genetic and maternal factors influencing teratogenicity.
- Provides insights for risk assessment of NSAID use during gestation.