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Related Experiment Video

Updated: Jun 4, 2026

Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster
06:45

Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster

Published on: November 21, 2018

A tripartite synapse model in Drosophila.

Rie Danjo1, Fumiko Kawasaki, Richard W Ordway

  • 1Department of Biology and Center for Molecular and Cellular Neuroscience, Pennsylvania State University, University Park, Pennsylvania, USA.

Plos One
|March 2, 2011
PubMed
Summary

Researchers developed a new Drosophila model to study tripartite synapses, which involve glia and neurons. This model will help uncover how glial cells influence brain function and neurological diseases.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Genetics

Background:

  • Tripartite synapses, involving glia and neuronal elements, are crucial for neurological health and disease.
  • Understanding glial roles in synaptic function is limited by a lack of suitable genetic models.
  • Invertebrate models are needed for large-scale genetic studies of conserved tripartite synapse mechanisms.

Purpose of the Study:

  • To establish a Drosophila tripartite synapse model for studying glial contributions to synaptic function.
  • To enable genetic analysis of conserved tripartite synapse mechanisms using forward genetics and genome-wide tools.

Main Methods:

  • Development of a Drosophila model exhibiting tripartite synapse characteristics.
  • Utilizing classical and cell-type specific genetic approaches in Drosophila.

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Examining Monosynaptic Connections in Drosophila Using Tetrodotoxin Resistant Sodium Channels
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Examining Monosynaptic Connections in Drosophila Using Tetrodotoxin Resistant Sodium Channels

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Last Updated: Jun 4, 2026

Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster
06:45

Electrophysiological Recording of The Central Nervous System Activity of Third-Instar Drosophila Melanogaster

Published on: November 21, 2018

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains
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Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains

Published on: November 6, 2017

Examining Monosynaptic Connections in Drosophila Using Tetrodotoxin Resistant Sodium Channels
09:55

Examining Monosynaptic Connections in Drosophila Using Tetrodotoxin Resistant Sodium Channels

Published on: February 14, 2018

  • Investigating glial regulation of extracellular glutamate and calcium signaling.

    • Main Results:

    • The Drosophila model displays morphological and functional similarities to mammalian tripartite synapses.
    • Demonstrated glial regulation of extracellular glutamate and synaptically-induced glial calcium transients.
    • Observed glial coupling of synapses with tracheal structures for gas exchange.

    Conclusions:

    • The established Drosophila tripartite synapse model offers a powerful platform for genetic research.
    • This model will advance understanding of the molecular and cellular mechanisms underlying tripartite synapse function.
    • Provides a foundation for future studies on glia-neuron interactions in neurological contexts.