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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Endovascular treatment of symptomatic intracranial atherosclerotic disease

Jody L Short1, Arshad Majid, Syed I Hussain

  • 1Department of Neurology, Michigan State University East Lansing, MI, USA.

Frontiers in Neurology
|March 2, 2011
PubMed

Insights

Symptomatic intracranial atherosclerotic disease (ICAD) causes 10% of US ischemic strokes. This review examines angioplasty and stenting for critical ICAD stenosis refractory to medical management.

Area of Science:

  • Neurology
  • Vascular Surgery
  • Interventional Radiology

Background:

  • Symptomatic intracranial atherosclerotic disease (ICAD) accounts for 10% of ischemic strokes in the US.
  • High-grade stenosis (>70%) in ICAD carries a significant risk of recurrent stroke (up to 35%).
  • Optimizing medical and endovascular treatments for ICAD is a key focus in stroke research.

Purpose of the Study:

  • To review the current state of endovascular treatment for symptomatic ICAD.
  • To evaluate the safety, suitability, and efficacy of angioplasty and/or stenting for critical ICAD stenoses.
  • To address the therapeutic strategy for patients with ICAD refractory to medical management.

Main Methods:

  • Comprehensive literature review of symptomatic ICAD studies.
  • Analysis of existing data on angioplasty and/or stenting in severe symptomatic ICAD.
  • Focus on case series and the need for randomized trial results.

Main Results:

  • Current data predominantly consists of case series for endovascular interventions in ICAD.
  • Randomized trial results comparing endovascular therapy to medical treatment are pending.
  • The efficacy and safety of angioplasty/stenting in refractory ICAD require further robust evidence.

Conclusions:

  • Angioplasty and/or stenting are potential therapeutic options for symptomatic ICAD.
  • Further randomized controlled trials are needed to establish definitive evidence for endovascular treatment efficacy in ICAD.
  • Optimizing treatment strategies for ICAD remains crucial for stroke prevention.

Keywords:
GatewayWingspanangioplastyintracranial angioplastyintracranial atherosclerosisintracranial stentingstentstroke

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