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Updated: Jun 4, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[Acute dyspnea in malignant melanoma]
1Klinik für HNO-Krankheiten und plastische Operationen, Ruppiner Kliniken GmbH, Fehrbelliner Straße 38, 16816, Neuruppin, Deutschland. a.franzen@ruppiner-kliniken.de
HNO
|March 2, 2011
Summary
Metastases to the larynx from cutaneous melanoma are rare but serious, often presenting years after initial treatment. This rare laryngeal metastasis indicates widespread cancer and has a fatal prognosis.
Area of Science:
- Oncology
- Otolaryngology
Background:
- Metastases to the larynx are uncommon, with laryngeal involvement representing a rare manifestation of disseminated cancer.
- Cutaneous melanoma is a significant primary malignancy with the potential for distant spread.
Observation:
- A case report details a 75-year-old patient with a supraglottic exophytic lesion causing shortness of breath.
- The lesion was histologically confirmed as a metastasis from a cutaneous melanoma diagnosed 2.5 years prior.
- A literature review identified approximately 30 published cases of laryngeal melanoma metastasis.
Findings:
- Primary cutaneous melanomas spread to the larynx typically present as supraglottic, exophytic, red-colored lesions.
- A significant time interval often exists between the primary cutaneous melanoma diagnosis and the development of laryngeal metastasis.
- Histological examination is essential for definitive diagnosis of laryngeal metastasis.
Implications:
- Laryngeal metastasis from cutaneous melanoma signifies advanced tumor dissemination.
- The prognosis for patients with laryngeal melanoma metastasis is universally fatal.
- Increased awareness and diagnostic vigilance for rare metastatic sites like the larynx are crucial in melanoma management.
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