Related Experiment Video
Updated: Jun 4, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[Acute dyspnea in malignant melanoma]
1Klinik für HNO-Krankheiten und plastische Operationen, Ruppiner Kliniken GmbH, Fehrbelliner Straße 38, 16816, Neuruppin, Deutschland. a.franzen@ruppiner-kliniken.de
Abstract:
Metastases to the larynx are rare. The current article presents the case of a 75-year-old patient with a history of shortness of breath due to a supraglottic exophytic lesion that was identified as a metastasis of a cutaneous melanoma treated 2.5 years previously. As a result of our medline analysis we found approximately 30 cases of metastatic melanoma to the larynx published to date. Primary tumors are always cutaneous in origin and spread over the whole integument of trunk and extremities. The time interval between diagnosis of the primary and the laryngeal metastasis is often several years. In most reports a supraglottic exophytic, red coloured lesion is described. Diagnosis can only be proven by histological examination. Laryngeal metastasis is usually an indication of tumor dissemination and always has a fatal prognosis.
Related Concept Videos
Acute Respiratory Failure-IV
Acute Respiratory Failure-III
Pneumothorax-II
Clinical Manifestations:
Pneumothorax-I
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD: