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Related Experiment Video

Updated: Jun 4, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Antisense Blockade of Expression : SNAP-25 In Vitro and In Vivo.

M Catsicas¹, A Osen-Sand, J K Staple

¹Glaxo Institute for Molecular Biology, Geneva, Switzerland.

Methods in Molecular Medicine

|March 2, 2011

Summary

This summary is machine-generated.

Modern molecular genetics identifies novel gene products with unknown functions. Determining gene function is crucial for understanding disease mechanisms and physiological processes.

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TGF-β-mediated Endothelial to Mesenchymal Transition (EndMT) and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing

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Published on: February 26, 2021

Area of Science:

Molecular Biology
Genetics

Background:

Modern molecular biology and genetics frequently identify novel gene products with undetermined functions.
Genetic linkage analysis can associate genes with diseases.
Sensitive cloning procedures identify rare genes in specific physiological or pathological contexts.

Purpose of the Study:

To highlight the importance of determining the function of newly identified genes.
To emphasize the role of gene function in understanding disease and physiology.

Main Methods:

Genetic linkage analysis.
Sensitive differential cloning procedures.

Main Results:

Novel gene products are increasingly identified.
Association of genes with diseases is possible through linkage analysis.
Rare genes in specific conditions can be identified via differential cloning.

Conclusions:

Establishing the precise function of identified genes is essential.
Understanding gene function is key to elucidating cellular mechanisms in disease and physiology.