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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

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Related Experiment Video

Updated: Jun 4, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Hyperthermia in soft tissue sarcoma.

Lars H Lindner1, Rolf D Issels

  • 1University of Munich, Munich, Germany. Lars.Lindner@med.uni-muenchen.de

Current Treatment Options in Oncology
|March 2, 2011
PubMed
Summary
This summary is machine-generated.

Regional hyperthermia (RHT) combined with chemotherapy significantly improves outcomes for high-risk soft tissue sarcomas (STS). This multimodal approach enhances treatment efficacy and reduces recurrence rates, offering a new standard of care.

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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Published on: January 13, 2023

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Protocol for Long Duration Whole Body Hyperthermia in Mice
07:56

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

Area of Science:

  • Oncology
  • Medical Physics

Background:

  • High-risk soft tissue sarcomas (STS) often recur or metastasize post-surgery.
  • Multidisciplinary management is crucial for effective STS treatment.

Purpose of the Study:

  • To evaluate the efficacy of regional hyperthermia (RHT) as an addition to standard treatments for high-risk STS.
  • To assess RHT's impact on tumor response, recurrence, and survival rates.

Main Methods:

  • RHT involves non-invasive electromagnetic heating of the tumor to 40-43°C for 60 minutes.
  • RHT is used adjunctively with radiotherapy and/or chemotherapy, not as a standalone treatment.
  • Studies analyzed RHT combined with neoadjuvant chemotherapy (doxorubicin/ifosfamide) and its addition to multimodal therapy post-surgery.

Main Results:

  • RHT combined with chemotherapy significantly improved tumor response rates and prevented early progression in the neoadjuvant setting.
  • Adding RHT to multimodal therapy (surgery, radiotherapy, chemotherapy) improved local recurrence-free and disease-free survival.
  • RHT demonstrated low toxicity, making it a safe addition to STS treatment.

Conclusions:

  • Regional hyperthermia is a promising fourth standard treatment modality for high-risk STS.
  • Combining RHT with preoperative or postoperative chemotherapy should be considered for locally advanced high-grade STS.
  • RHT enhances chemotherapy and radiotherapy efficacy, improving patient survival and reducing recurrence.