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Increased systemic inflammation overnight correlates with insulin resistance among children evaluated for obstructive

Mark D Deboer1, James P Mendoza, Lei Liu

  • 1Division of Pediatric Endocrinology, P.O. Box 800386, Charlottesville, VA 22908, USA. deboer@virginia.edu

Sleep & Breathing = Schlaf & Atmung
|March 2, 2011
PubMed

Insights

In children suspected of obstructive sleep apnea (OSA), insulin resistance, not OSA severity, may drive overnight inflammation. Further research is needed to understand these links.

Area of Science:

  • Pediatric Sleep Medicine
  • Endocrinology
  • Inflammation Research

Background:

  • Obstructive sleep apnea (OSA) in children is linked to obesity, insulin resistance, and elevated inflammation (hsCRP).
  • The relationship between OSA, obesity, insulin resistance, and overnight inflammation in children requires further investigation.

Purpose of the Study:

  • To determine if inflammation increases overnight in children with suspected OSA.
  • To assess if increased inflammation correlates with OSA severity, obesity, or insulin resistance.

Main Methods:

  • Twenty-three children underwent sleep studies with hsCRP measured pre- and post-sleep.
  • Insulin resistance was calculated using HOMA-IR from fasting glucose and insulin levels.
  • Correlations analyzed hsCRP changes (ΔhsCRP) against HOMA-IR, BMI z-score, and sleep study parameters (AHI, O2 saturation).

Main Results:

  • hsCRP levels correlated with HOMA-IR and BMI z-scores in the overall cohort.
  • Overnight hsCRP change (ΔhsCRP) correlated with HOMA-IR but not BMI z-score.
  • Sleep study parameters (AHI, O2 saturation nadirs) did not correlate with hsCRP or ΔhsCRP.

Conclusions:

  • Insulin resistance may be a key factor in overnight inflammation increase among children evaluated for OSA.
  • Overnight inflammation increase was not linked to OSA severity markers from sleep studies.
  • The precise role of OSA in overnight inflammation and its mechanisms remain unclear, necessitating further research.
Abstract

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