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Updated: Jun 4, 2026

A Behavioral Assay for Mechanosensation of MARCM-based Clones in Drosophila melanogaster
Published on: December 30, 2015
Genetics of mechanosensation in the heart
Byambajav Buyandelger1, Keat-Eng Ng, Snjezana Miocic
1Myocardial Genetics, British Heart Foundation-Centre for Research Excellence, National Heart & Lung Institute, Imperial College, South Kensington Campus, London, UK. r.knoell@imperial.ac.uk
Abstract:
Mechanosensation (the ultimate conversion of a mechanical stimulus into a biochemical signal) as well as mechanotransduction (transmission of mechanically induced signals) belong to the most fundamental processes in biology. These effects, because of their dynamic nature, are particularly important for the cardiovascular system. Therefore, it is not surprising that defects in cardiac mechanosensation, are associated with various types of cardiomyopathy and heart failure. However, our current knowledge regarding the genetic basis of impaired mechanosensation in the cardiovascular system is beginning to shed light on this subject and is at the centre of this brief review.
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