Related Experiment Video
Updated: Jun 4, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
[Mixed leg ulcers]
1Universitätsklinik für Angiologie, Schweizer Herz- und Gefäßzentrum, Inselspital, Bern. torsten.willenberg@insel.ch
Insights
Peripheral arterial disease often coexists with venous leg ulcers, affecting 15-21% of patients. Treatment must address both arterial and venous components for effective healing.
Area of Science:
- Vascular Surgery
- Dermatology
- Wound Healing
Context:
- Ulcera cruris (leg ulcers) commonly have a venous etiology.
- A significant percentage (15-21%) of patients with venous leg ulcers also have coexisting peripheral arterial disease.
- Diagnosing mixed arterial-venous ulcers requires a comprehensive approach including patient history, clinical examination, ankle-brachial index (ABI), and duplex ultrasonography.
Purpose:
- To highlight the prevalence and diagnostic challenges of mixed arterial-venous leg ulcers.
- To emphasize the necessity of evaluating and treating the arterial component in these ulcers.
- To outline current treatment strategies for mixed leg ulcers.
Summary:
- Mixed arterial-venous leg ulcers necessitate a dual treatment approach.
- Endovascular revascularization can significantly improve arterial perfusion and promote healing.
- Compression therapy, potentially with advanced graduated systems, remains crucial for the venous component, alongside consideration for varicose vein ablation.
Impact:
- Improved diagnostic accuracy for complex leg ulcers.
- Enhanced treatment outcomes through integrated management of arterial and venous pathologies.
- Reduced recurrence rates and improved quality of life for patients with mixed leg ulcers.
Abstract:
Coexisting peripheral arterial disease is not uncommon (15 - 21 %) in patients with ulcera cruris primarily based on a venous etiology. Patient's history, clinical examination and detection of ABI as well as duplex scan will establish diagnosis of mixed arterial-venous ulcera. Clinical significance of coexisting arterial disease is often difficult to define and should be evaluated by a vascular specialist. The concept of treatment of mixed ulcers should always include the arterial component. Frequently peripheral arterial perfusion and healing can be improved by minimal invasive, endovascular revascularization. Compression therapy is the corner stone in treatment of venous disease and should be complemented by contemporary two piece graduated compression systems if ulcera are present. According to circumstances ablation of varicose veins must be considered.
Related Concept Videos
Diabetic Foot Ulcer
Peptic Ulcer
Peptic Ulcer Disease III: Clinical Manifestations and Complications
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Varicose Veins I: Introduction
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation