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Selenium supplementation increases renal glomerular filtration rate.

G C Guidi1, G Bellisola, G Bonadonna

  • 1Laboratorio di Chimica Clinica, C.O.C. Valeggio s/M., Italy.

Journal of Trace Elements and Electrolytes in Health and Disease
|September 1, 1990
PubMed
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Oral selenium supplementation in healthy volunteers improved kidney function. Selenium intake led to lower serum creatinine and increased creatinine clearance, suggesting a positive impact on glomerular filtration rate.

Area of Science:

  • Nephrology
  • Trace Element Metabolism
  • Human Physiology

Background:

  • Selenium (Se) is a vital trace element concentrated in organs like the renal cortex.
  • Preliminary observations suggested a potential role for Se in regulating renal glomerular filtration rate.

Purpose of the Study:

  • To investigate the effect of oral selenium supplementation on renal function.
  • To evaluate changes in glomerular filtration rate and serum creatinine levels.

Main Methods:

  • A ten-week oral selenium (sodium selenite) supplementation study was conducted with eleven healthy volunteers.
  • Dosage increased weekly from 100 to 700 micrograms/day.
  • Serum and urine samples were collected weekly for creatinine and Se level analysis.

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Main Results:

  • Mean serum creatinine concentration decreased by 13% (p<0.01).
  • Mean creatinine clearance significantly increased (p<0.05) and correlated directly with Se clearance (r=0.79, p<0.001).
  • No toxic effects were observed.

Conclusions:

  • Oral selenium supplementation positively influences glomerular filtration rate.
  • Selenium may play a role in the kidney's vascular regulatory mechanisms.