Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphologic changes in cerebral arteries after subarachnoid hemorrhage.

M R Mayberg1, T Okada, D H Bark

  • 1Department of Neurological Surgery, University of Washington School of Medicine, Seattle.

Neurosurgery Clinics of North America
|April 1, 1990
PubMed
Summary

Subarachnoid hemorrhage causes cerebral artery morphologic changes, leading to ischemic deficits. Hemoglobin from red blood cells is implicated in this arterial response and vasospasm.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reversal of acute ischemic hypodense lesions on computed tomography.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Reversible basilar artery blood flow in subclavian steal syndrome.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis.

Lancet (London, England)·2003
Same author

Gamma knife radiosurgery in the management of patients with acromegaly: a review.

Pituitary·2002
Same author

Long-term durability of carotid endarterectomy for symptomatic stenosis and risk factors for late postoperative stroke.

Stroke·2002
Same author

Serum S-100beta as a possible marker of blood-brain barrier disruption.

Brain research·2002

Area of Science:

  • Neuroscience
  • Vascular Biology
  • Pathology

Background:

  • Subarachnoid hemorrhage (SAH) is a critical condition often leading to ischemic deficits.
  • Cerebral artery morphologic changes are hypothesized to contribute to SAH pathogenesis.
  • The response of cerebral arteries to SAH shares similarities with systemic vascular pathologies.

Purpose of the Study:

  • To investigate the role of morphologic changes in cerebral arteries following SAH.
  • To explore the pathogenic mechanisms linking SAH to ischemic deficits.
  • To compare the arteriopathic response in SAH with systemic vascular conditions.

Main Methods:

  • Analysis of morphologic changes in human and animal cerebral arteries post-SAH.
  • Correlation of structural changes with angiographic and clinical vasospasm.

Related Experiment Videos

  • Investigation of the cellular components of blood responsible for arterial alterations.

    • Main Results:

    • Morphologic changes in cerebral arteries are temporally linked to vasospasm after SAH.
    • Structural changes do not increase vessel wall mass but may interact with contractile mechanisms to narrow the lumen.
    • Hemoglobin, from erythrocytes, is identified as the likely agent causing arterial narrowing and morphologic changes.
    • The volume and duration of blood exposure influence the angiopathic response.
    • Ultrastructural abnormalities in SAH resemble those in systemic vascular diseases like hypertension and atherosclerosis.

    Conclusions:

    • Morphologic alterations in cerebral arteries are key in SAH-induced ischemic deficits.
    • Hemoglobin is a critical factor in SAH-induced cerebral vasospasm and arteriopathy.
    • SAH-related cerebral artery pathology shares common mechanisms with other vascular diseases.