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Related Experiment Video

Updated: Jun 4, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
09:31

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Published on: March 30, 2015

Revealing retroperitoneal liposarcoma morphology using optical coherence tomography.

Esteban F Carbajal, Stepan A Baranov, Venu G R Manne

    Journal of Biomedical Optics
    |March 3, 2011
    PubMed
    Summary

    Optical coherence tomography (OCT) offers a new method to differentiate normal fat from liposarcoma (LS) tumors. This imaging technique visualizes structures similar to histology, aiding in diagnosis.

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    Area of Science:

    • Biomedical Imaging
    • Oncology
    • Pathology

    Background:

    • Distinguishing between normal adipose tissue, well-differentiated liposarcoma (WDLS), and dedifferentiated liposarcoma (DDLS) is crucial for effective cancer treatment.
    • Conventional diagnostic methods rely on histopathology, which can be time-consuming and requires specialized expertise.

    Discussion:

    • Optical coherence tomography (OCT) provides high-resolution, real-time imaging of tissue microstructure.
    • OCT images reveal structural details comparable to traditional histological examination, enabling visual grading of tissue types.
    • Numerical analysis of OCT-imaged structures in normal fat and WDLS samples supports visual assessment, enhancing diagnostic accuracy.

    Key Insights:

    • A novel OCT-based approach demonstrates potential for differentiating normal fat, WDLS, and DDLS.

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    Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
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    Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography

    Published on: February 9, 2019

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    Last Updated: Jun 4, 2026

    In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
    09:31

    In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

    Published on: March 30, 2015

    Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
    08:50

    Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography

    Published on: February 9, 2019

  • The technique visualizes key histological features, facilitating non-invasive tumor characterization.
  • Combined visual and numerical analysis of OCT data improves diagnostic reliability for liposarcoma subtypes.

    • Outlook:

    • Further development of OCT technology could enable real-time intraoperative margin assessment during liposarcoma surgery.
    • OCT's high resolution and speed offer advantages for rapid, point-of-care diagnosis of liposarcoma.
    • Integration of OCT into clinical workflows may improve patient outcomes through earlier and more precise diagnosis.