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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 4, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Published on: August 28, 2015

Drug-loaded biodegradable microspheres for image-guided combinatory epigenetic therapy in cells.

Ronald X Xu, Jeff S Xu, Tao Zuo

    Journal of Biomedical Optics
    |March 3, 2011
    PubMed
    Summary

    We developed biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres for targeted, image-guided epigenetic therapy. These microspheres deliver drugs to inhibit cancer pathways and demethylate DNA in breast cells.

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    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
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    Published on: October 31, 2025

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    Last Updated: Jun 4, 2026

    Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
    07:32

    Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

    Published on: August 28, 2015

    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
    09:56

    Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins

    Published on: October 31, 2025

    Area of Science:

    • Biomaterials Science
    • Nanotechnology
    • Epigenetics

    Background:

    • Development of biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres for drug delivery.
    • Encapsulation of LY294002 (PI3K/AKT inhibitor) and Nile Red (fluorescent imaging agent) within PLGA microspheres.
    • Design of a three-step targeting mechanism for specific cell adhesion using biotinylated antibodies, streptavidin, and biotinylated microspheres.

    Discussion:

    • Investigating the sustained release of LY294002 and Nile Red for effective therapeutic intervention and real-time monitoring.
    • Evaluating the combinatory epigenetic therapy approach using LY294002-loaded microspheres and 5-Aza-2-deoxycytidine.
    • Assessing the dual action of PI3K/AKT inhibition and DNA demethylation in MCF-10A human mammary epithelial cells.

    Key Insights:

    • Successful synthesis of multifunctional, biodegradable PLGA microspheres for targeted drug delivery.
    • Demonstration of image-guided therapy through fluorescence microscopy using Nile Red-loaded microspheres.
    • Confirmation of combinatory epigenetic effects, including PI3K/AKT pathway inhibition and DNA demethylation.

    Outlook:

    • Exploring the potential of these microspheres for advanced disease targeting and image-guided therapeutic strategies.
    • Further investigation into the long-term efficacy and safety of PLGA microsphere-based epigenetic therapy.
    • Expanding the application of this technology to other cancer types and therapeutic agents.