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Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...

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Studying Cell Death Initiation Using a Digital Microscope
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Detecting cell death with optical coherence tomography and envelope statistics.

Golnaz Farhat1, Victor X D Yang, Gregory J Czarnota

  • 1University of Toronto, Department of Medical Biophysics, Toronto, Ontario, M5G 2M9, Canada. golnaz.farhat@gmail.com

Journal of Biomedical Optics
|March 3, 2011
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography (OCT) can now detect cell death by analyzing changes in integrated backscatter and signal envelope statistics. This noninvasive optical method shows promise for monitoring cancer treatment in preclinical and clinical settings.

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Published on: February 9, 2019

Area of Science:

  • Biomedical Optics
  • Cell Biology
  • Medical Imaging

Background:

  • Noninvasive monitoring of cell death remains a clinical challenge.
  • Quantitative high-frequency ultrasound has previously shown potential for detecting cell death.
  • Optical Coherence Tomography (OCT) offers high-resolution imaging capabilities.

Purpose of the Study:

  • To adapt quantitative ultrasound methods for OCT to detect cell death.
  • To explore OCT's potential for noninvasive cancer treatment monitoring.
  • To differentiate between various modes of cell death using OCT.

Main Methods:

  • Acquired OCT data from acute myeloid leukemia cells undergoing apoptosis, mitotic arrest, and necrosis.
  • Analyzed integrated backscatter and signal envelope statistics.
  • Correlated OCT findings with histology of cell samples.
  • Applied generalized gamma distribution to analyze envelope intensity histograms.

Main Results:

  • Significant increases in integrated backscatter observed during apoptosis and mitotic arrest.
  • A decrease in integrated backscatter noted in necrotic cells.
  • OCT signal envelope statistics showed sensitivity to cellular morphological changes.
  • Results suggest OCT can detect and differentiate modes of cell death.

Conclusions:

  • Quantitative OCT parameters, specifically integrated backscatter and envelope statistics, can detect in vitro cell death.
  • These findings support OCT's potential for noninvasive monitoring of cancer therapies.
  • Further research may enable clinical application for treatment response assessment.