Related Experiment Video
Updated: Jun 4, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Coincidental thyroid papillary microcarcinoma in a patient treated for a toxic adenoma of the thyroid
Stergios A Polyzos1, Dimitrios G Goulis
1Second Medical Clinic, Medical School, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece. stergios@endo.gr
Abstract:
Thyroid carcinoma is not uncommon in patients with hyperthyroidism. However, the risk of malignancy in patients with autonomously functioning nodules continues to be underestimated in clinical practice, possibly due to the belief of rare co-existence of a "hot" nodule and thyroid carcinoma. We present hereby a man with hyperthyroidism due to a thyroid toxic adenoma, who was subjected to surgery and incidentally found to have a papillary thyroid microcarcinoma on the contralateral thyroid lobe. By reviewing the literature, incidental thyroid carcinoma in patients subjected to thyroidectomy for a hyperfunctioning nodule, both within and out of the nodule is not a rare event. However, the incidental finding of thyroid carcinoma out of a hyperfunctioning nodule is not adequately reviewed in the literature.
Related Concept Videos
Hyperthyroidism II: Pathophysiology
Hyperthyroidism I: Introduction
Graves Disease II: Pathophysiology
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Graves' Disease I: Introduction
Goiter

