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Related Experiment Videos

Bilateral Wilms tumors.

R A Garrett, J P Donohue

    The Journal of Urology
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Bilateral Wilms tumor management is challenging due to concurrent anomalies. Survival is possible with surgery, chemotherapy, and radiotherapy, but standardized treatment is lacking.

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    Area of Science:

    • Pediatric Oncology
    • Nephrology
    • Surgical Oncology

    Background:

    • Bilateral Wilms tumor is a rare pediatric kidney cancer.
    • Concurrent congenital anomalies are frequently observed in patients with bilateral Wilms tumor.
    • Current management strategies lack standardization, posing treatment challenges.

    Purpose of the Study:

    • To review the current management approaches for bilateral Wilms tumor.
    • To highlight the high incidence of associated anomalies in these patients.
    • To assess outcomes and survival rates following various treatment modalities.

    Main Methods:

    • Retrospective review of 5 pediatric patients diagnosed with bilateral Wilms tumor.
    • Analysis of treatment interventions including surgical procedures (nephrectomy, partial nephrectomy, allotransplant).

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  • Evaluation of adjuvant therapies such as chemotherapy and radiotherapy.

    • Main Results:

    • Four out of five patients (80%) presented with concurrent anomalies.
    • Three patients survived for 30 months to 11 years with no tumor recurrence.
    • Treatment included unilateral/partial nephrectomies or bilateral nephrectomy with allotransplantation, combined with chemotherapy and radiotherapy.

    Conclusions:

    • Bilateral Wilms tumor management requires a multidisciplinary approach.
    • Effective treatment can be achieved with surgery and adjuvant therapies, despite associated anomalies.
    • Further research is needed to establish standardized treatment protocols for improved outcomes.