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Updated: Jun 4, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Effect of a contusion injury on muscular force, power, work, and fatigue
S Elmer1, J McDaniel, J Mattson
1Department of Exercise and Sport Science, The University of Utah, Salt Lake City, Utah, USA.
Abstract:
The purpose of the investigation was to compare alterations in muscular force, power, work, and fatigue following a contusion injury. We hypothesized that power and work would be more greatly reduced than isometric force due to several mechanisms that would alter the force-velocity relationship and impair activation/relaxation kinetics specific to dynamic muscle contractions. Contusion injury was administered to the gastrocnemius muscle of adult rats using the drop-mass technique. Isometric force, power during shortening (10, 25, and 40 mm/s), work produced during cyclic contractions (2 and 4 Hz), and fatigue during 60 work loops, were normalized to dry muscle mass and analyzed in control animals (n=11), as well as 1 h (n=11) and 48 h (n=9) following contusion injury. Passive work increased (30-38%) 48 h after injury compared with control (P<0.01). Isometric force, power, and work were significantly reduced by similar magnitudes 1 h (28-33%) and 48 h (28-38%) after injury compared with control (P<0.01). Fatigue index 1 h post-injury was significantly less than control (75% vs 85%; P=0.02). The observed increases in muscle hysteresis were apparently not large enough to cause greater reductions in power and work than isometric force. We conclude that isometric measures provide adequate quantification of muscular dysfunction following a contusion injury in these animals and may offer sufficient information to determine recovery status in clinical settings as well.
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