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Prognosis following first-time myocardial infarction in patients with psoriasis: a Danish nationwide cohort study

O Ahlehoff1, G H Gislason, J Lindhardsen

  • 1Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark. olahha01@geh.regionh.dk

Journal of Internal Medicine
|March 3, 2011
PubMed

Insights

Psoriasis patients face a worse prognosis after a first myocardial infarction (MI). This study found increased risks of death and cardiovascular events in individuals with psoriasis post-MI.

Area of Science:

  • Cardiology
  • Dermatology
  • Epidemiology

Background:

  • The cardiovascular risk associated with psoriasis is debated.
  • The prognostic impact of psoriasis following myocardial infarction (MI) remains unknown.

Purpose of the Study:

  • To investigate the risk of mortality and adverse cardiovascular events in patients with psoriasis following their first MI.

Main Methods:

  • A nationwide cohort study of the Danish population (2002-2006).
  • Utilized multivariable Cox regression to assess post-MI prognosis in psoriasis patients.
  • Main outcomes included all-cause mortality and a composite cardiovascular endpoint (recurrent MI, stroke, cardiovascular death).

Main Results:

  • 462 psoriasis patients and 48,935 controls with first MI were identified.
  • Psoriasis was associated with a trend towards increased all-cause mortality (HR 1.18; 95% CI 0.97-1.43).
  • Psoriasis significantly increased the risk of the composite cardiovascular endpoint (HR 1.26; 95% CI 1.04-1.54).

Conclusions:

  • Psoriasis is associated with a significantly impaired prognosis after a first myocardial infarction.
  • This study highlights a novel association warranting further investigation.
Abstract

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