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Increased Lipoprotein (a) concentrations in patients with chronic venous leg ulcers: a study on patients with or

Markus Zutt1, Ulrich Krüger, Albert Rosenberger

  • 1Department of Dermatology, Venereology and Allergology, University of Göttingen, Göttingen, Germany. mzutt@gwdg.de

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [And] the European Tissue Repair Society
|March 3, 2011
PubMed

Insights

Elevated Lipoprotein (a) [Lp(a)] levels are common in patients with chronic venous leg ulcers, suggesting it may be a novel pathogenic factor. This finding could improve understanding and treatment of these ulcers.

Area of Science:

  • Vascular Medicine
  • Thrombosis Research
  • Dermatology

Background:

  • Chronic venous leg ulcers represent a significant global health burden with complex, not fully understood pathophysiology.
  • Current knowledge gaps exist regarding reliable pathogenic and prognostic markers for these ulcers.
  • Existing data suggest a link between venous leg ulcers and thrombophilia.

Purpose of the Study:

  • To investigate serum Lipoprotein (a) [Lp(a)] levels in patients with chronic venous leg ulcers.
  • To determine if Lp(a) serves as a pathogenic or prognostic parameter in this patient population.
  • To compare Lp(a) levels between patients with and without postthrombotic syndrome and healthy controls.

Main Methods:

  • Serum Lp(a) levels were measured in 210 patients with chronic venous leg ulcers (stratified by postthrombotic syndrome) and 341 healthy controls.
  • Statistical analysis was performed to compare Lp(a) concentrations across the groups.
  • Correlation between Lp(a) and C-reactive protein (CRP) levels was assessed.

Main Results:

  • Significantly higher Lp(a) serum concentrations (>0.3 g/L) were observed in 42% of patients with venous leg ulcers compared to 20% of healthy controls.
  • Increased Lp(a) levels were found in 49% of patients without postthrombotic syndrome versus 35% with the syndrome.
  • Significant differences in Lp(a) levels were noted among all three groups (p<0.001), with no correlation to CRP values.

Conclusions:

  • Serum Lp(a) level is a potential novel pathogenic parameter for chronic venous leg ulcers.
  • Elevated Lp(a) may contribute to ulcer pathogenesis via thrombogenic microcirculatory dysregulation or impaired fibrinolysis.
  • Further research is warranted to elucidate the precise mechanisms of Lp(a) in venous leg ulcer development.

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