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Updated: Jun 4, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Vaginal oestrogen therapy in women with hormone-sensitive breast cancer]
Ann Mosegaard Bak1, Britt Elmedal Laursen, Jørgen Rungby
1Klinisk Farmakologisk Afdeling, Århus Universitetshospital, 8000 Aarhus C, Denmark. ann.m.bak@gmail.com
Abstract:
Vaginal atrophy is a common problem in women who have previously been treated for breast cancer. Endocrine therapy plays an essential role in the treatment of breast cancer. Systemic hormonal treatment is contraindicated. Topical oestrogens are an effective treatment for vaginal atrophy, but are poorly studied in this group of patients. Physicians are reluctant to recommend it because of the potential increase in the risk of recurrence. The sparse data available suggest that vaginal oestrogen may be used relatively safely by women who are in tamoxifen treatment, but should not be used by women who receive aromatase inhibitor treatment.
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