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Updated: Jun 4, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Clever leukemic stem cells branch out
Paresh Vyas1, Sten Eirik W Jacobsen
1MRC Molecular Haematology Unit, Radcliffe Hospital, Oxford OX3 9DU, UK. paresh.vyas@imm.ox.ac.uk
Abstract:
Individual tumors harbor heterogeneous populations of genetically distinct subclones. Two recent papers in Nature by Notta et al. (2011) and Anderson et al. (2011) reveal genetic heterogeneity in functional leukemic stem cells, which has important implications for how both cancer and normal stem cell populations may adapt to selective pressure.
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