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Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

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Related Experiment Video

Updated: Jun 4, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Food allergy.

Julie Wang¹, Hugh A Sampson

¹Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai Hospital, New York, New York, USA. julie.wang@mssm.edu

The Journal of Clinical Investigation

|March 3, 2011

Summary

This summary is machine-generated.

Food allergies impact many children and adults, involving complex immune responses and various conditions. Advances in understanding these interactions are paving the way for new diagnostic and therapeutic strategies.

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Published on: September 14, 2018

Area of Science:

Immunology
Allergy and Immunology
Gastroenterology

Background:

Food allergies are prevalent, affecting up to 6% of children and 3%-4% of adults.
These allergies encompass diverse IgE and/or non-IgE mediated disorders, including anaphylaxis, pollen food syndrome, food-protein-induced enterocolitis syndrome, food-induced proctocolitis, eosinophilic gastroenteropathies, and atopic dermatitis.

Purpose of the Study:

To review the current understanding of food allergy pathogenesis.
To highlight recent advances in diagnostic and therapeutic strategies for food allergies.

Main Methods:

Literature review of recent advances in food allergy research.
Synthesis of information on host factors and food properties influencing allergy development.

Main Results:

Complex interactions between host factors and food properties contribute to food allergy development.
Emerging diagnostic and therapeutic strategies show promise for managing food allergies.

Conclusions:

Continued research into the multifactorial nature of food allergies is crucial.
Novel approaches are being developed to improve the diagnosis and treatment of food allergies.