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Updated: Jun 4, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Therapeutic hypothermia for space-occupying Herpes simplex virus encephalitis
I Wagner1, D Staykov, B Volbers
1Department of Neurology, University Hospital of Erlangen, University of Erlangen-Nuremberg, Erlangen, Germany. ingrid.wagner@uk-erlangen.de
Induced moderate hypothermia effectively controlled intracranial pressure in a patient with severe Herpes simplex virus encephalitis. This aggressive treatment option led to a good functional outcome, offering hope for managing this severe neurological condition.
Area of Science:
- Neurology
- Infectious Diseases
- Critical Care Medicine
Background:
- Space-occupying edema in severe Herpes simplex virus encephalitis significantly contributes to patient morbidity and mortality.
- Conventional intracranial pressure management strategies often prove insufficient for severe cases.
- Limited aggressive treatment options have been described for refractory intracranial pressure in this condition.
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