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Updated: Jun 4, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Optical coherence tomography for the quantitative study of cerebrovascular physiology
Vivek J Srinivasan1, Dmitriy N Atochin, Harsha Radhakrishnan
1Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. vjsriniv@nmr.mgh.harvard.edu
None:
Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.
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