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Related Concept Videos

The Proteasome Structure01:17

The Proteasome Structure

The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...
The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
The Proteasome01:13

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin...
The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...

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Related Experiment Video

Updated: Jun 4, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

ProCoS: Protein composition server.

Lavanya Rishishwar, Neha Mishra, Bhasker Pant

    Bioinformation
    |March 3, 2011
    PubMed
    Summary
    This summary is machine-generated.

    ProCoS is a free online tool for calculating peptide compositions from multiple sequences. This user-friendly software offers flexible analysis and easy result visualization for bioinformatics research.

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    A Protein Suspension-Trapping Sample Preparation for Tear Proteomics by Liquid Chromatography-Tandem Mass Spectrometry

    Published on: December 1, 2023

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    Last Updated: Jun 4, 2026

    Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
    10:58

    Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

    Published on: July 25, 2013

    A Protein Suspension-Trapping Sample Preparation for Tear Proteomics by Liquid Chromatography-Tandem Mass Spectrometry
    08:20

    A Protein Suspension-Trapping Sample Preparation for Tear Proteomics by Liquid Chromatography-Tandem Mass Spectrometry

    Published on: December 1, 2023

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Biochemistry

    Background:

    • Peptide composition analysis is crucial in bioinformatics.
    • Existing tools may lack flexibility or ease of use for complex analyses.
    • Handling multiple sequence inputs and varied compositional metrics presents a challenge.

    Purpose of the Study:

    • To introduce ProCoS, a novel, free online tool for computing peptide compositions.
    • To provide a flexible and user-friendly platform for analyzing amino acid sequences.
    • To enable efficient visualization and analysis of sequence data.

    Main Methods:

    • Development of ProCoS as a web-based applet and server.
    • Implementation of a generalized algorithm for poly-amino acid composition calculation.
    • Support for multiple FASTA sequence inputs and analysis of full or partial sequences.

    Main Results:

    • ProCoS computes diverse combinations of peptide compositions.
    • The tool handles multiple FASTA sequences efficiently.
    • Output is provided in various formats for clear data visualization.
    • Analysis can be performed on entire sequences or specific regions.

    Conclusions:

    • ProCoS is a unique, user-friendly, and flexible tool for peptide composition analysis.
    • It simplifies complex compositional calculations in bioinformatics.
    • The software facilitates efficient data interpretation and research.