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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...

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Updated: Jun 4, 2026

Strategy for Biobanking of Ovarian Cancer Organoids: Addressing the Interpatient Heterogeneity across Histological Subtypes and Disease Stages
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[Personalized medicine 2011].

H E Blum

    Deutsche Medizinische Wochenschrift (1946)
    |March 3, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Molecular and cell biology advances disease understanding, diagnosis, and treatment. Genetic and epigenetic analyses enable personalized medicine by predicting disease risk and treatment efficacy.

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    Area of Science:

    • Molecular and cell biology
    • Genetics
    • Epigenetics
    • Biochemistry

    Background:

    • Molecular and cell biology research has significantly improved understanding of human disease pathogenesis.
    • Modern genetic, epigenetic, and biochemical analyses allow identification of specific mutations and epigenetic modifications.

    Discussion:

    • High-throughput array technologies enable simultaneous analysis of thousands of genes, creating individual gene expression profiles.
    • These profiles are crucial for defining individual disease risk and predicting prognosis.
    • The data supports the development of personalized medicine strategies.

    Key Insights:

    • Identification of point mutations, single nucleotide polymorphisms (SNPs), and epigenetic modifications.
    • Generation of individual gene or gene expression profiles (signatures) using high-throughput technologies.
    • Enabling personalized risk assessment, prognosis prediction, and therapeutic strategy selection.

    Outlook:

    • Molecular and cell biology are foundational to the advancement of personalized medicine.
    • Continued research will refine the prediction of disease risk and treatment outcomes.
    • Integration of multi-omics data will further enhance diagnostic and therapeutic precision.