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Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Published on: March 14, 2017

Partial exchange transfusion for polycythemia hyperviscosity syndrome.

Bridget Hopewell1, Laurie A Steiner, Richard A Ehrenkranz

  • 1Yale University School of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

American Journal of Perinatology
|March 3, 2011
PubMed
Summary
This summary is machine-generated.

Partial exchange transfusion (PET) for polycythemia hyperviscosity syndrome (PHS) in infants showed no change in usage over time. PHS and PET are linked to complications, necessitating further research on their long-term risks and benefits.

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Published on: June 14, 2024

Area of Science:

  • Neonatology
  • Pediatric Hematology

Background:

  • Polycythemia hyperviscosity syndrome (PHS) is a condition affecting newborns.
  • Risk factors for PHS include maternal diabetes, and it can lead to significant complications.

Purpose of the Study:

  • To analyze the trends in partial exchange transfusion (PET) for PHS in infants.
  • To evaluate the associated risk factors and complications of PHS and PET.

Main Methods:

  • Retrospective review of 141 infants treated with PET for PHS between 1986 and 2007.
  • Data collected included patient demographics, PHS risk factors, PET indications, and complications.

Main Results:

  • No significant change in the number of PET procedures performed over the 20-year study period.
  • Maternal diabetes decreased as a risk factor over time.
  • Forty percent of patients experienced PHS complications pre-PET; 18% had PET-related complications. Life-threatening events were rare.

Conclusions:

  • PHS remains a concern in neonatal intensive care units, especially in high-risk infants.
  • Both PHS and PET are associated with notable complications.
  • Further long-term studies are required to fully understand the risks and benefits of PET for PHS.