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Published on: December 18, 2010
Association between lymphotoxin-α intron +252 polymorphism and sepsis: a meta-analysis
Huang Tiancha1, Wang Huiqin, Jing Jiyong
1Intensive Care Unit, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Scandinavian Journal of Infectious Diseases
|March 4, 2011
Summary
The lymphotoxin-α (LTA) +252 A/G polymorphism is linked to increased sepsis risk and mortality. This genetic factor appears more influential in Caucasian populations, impacting both sepsis development and survival outcomes.
Area of Science:
- Genetics
- Immunology
- Critical Care Medicine
Background:
- Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
- Genetic factors play a role in sepsis susceptibility and outcomes.
- The lymphotoxin-α (LTA) gene, also known as tumor necrosis factor-β, is involved in immune regulation.
Purpose of the Study:
- To evaluate the association between the lymphotoxin-α (LTA) +252 A/G polymorphism and sepsis.
- To investigate the impact of this polymorphism on sepsis susceptibility and mortality.
Main Methods:
- Systematic literature search of MEDLINE, EMBASE, and Web of Science (1966-2010).
- Independent selection and data extraction by two reviewers.
- Meta-analysis of 27 studies involving 4399 septic patients.
Main Results:
- The LTA AA genotype was significantly associated with increased sepsis development (OR 1.33, p=0.006) compared to AG/GG genotypes.
- The LTA AA genotype was also associated with higher sepsis-related mortality (OR 1.89, p=0.002).
- Associations appeared stronger in Caucasian populations for both susceptibility and mortality.
Conclusions:
- The LTA +252 A/G polymorphism is a significant genetic factor associated with both susceptibility to and mortality from sepsis.
- This genetic variation may influence sepsis outcomes differently across ethnic groups.
