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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Deep penetrating nevus: a review.

Bostjan Luzar¹, Eduardo Calonje

¹Institute of Pathology, Medical Faculty University of Ljubljana, Slovenia.

Archives of Pathology & Laboratory Medicine

|March 4, 2011

Summary

Deep penetrating nevi can mimic melanoma, presenting concerning histologic features like atypia and asymmetry. However, these features do not indicate malignancy in deep penetrating nevi, distinguishing them from melanoma.

Area of Science:

Dermatopathology
Oncology

Background:

Deep penetrating nevus is a unique melanocytic lesion.
It can resemble melanoma clinically and histologically.

Purpose of the Study:

Review clinical and histologic characteristics of deep penetrating nevi.
Discuss differential diagnosis, particularly distinguishing from melanoma.

Main Methods:

Literature review on deep penetrating nevi.
Incorporation of personal clinical and histologic experience.

Main Results:

Deep penetrating nevi often exhibit concerning histologic features.
These include asymmetry, dermal nests, cytologic atypia, and lack of maturation.
Occasional dermal mitoses and inflammatory infiltrates may also be present.

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Conclusions:

Histologic features in deep penetrating nevi can be misleading.
Features such as atypia and asymmetry should not be interpreted as signs of malignancy.
Accurate diagnosis is crucial for distinguishing from melanoma.