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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Related Experiment Video

Updated: Jun 4, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Lentiginous melanoma.

Roy King1

  • 1University of Tennessee, Knoxville Dermatopathology Laboratory, 37919, USA. royelisa@tds.net

Archives of Pathology & Laboratory Medicine
|March 4, 2011
PubMed
Summary
This summary is machine-generated.

Lentiginous melanoma is a slow-growing melanoma subtype in older adults, presenting diagnostic challenges. Early identification and wide excision are crucial due to potential progression to invasive melanoma.

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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
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Last Updated: Jun 4, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Published on: June 7, 2019

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
08:39

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Atypical lentiginous melanocytic lesions in older individuals pose diagnostic challenges, often appearing intermediate between nevus and melanoma in situ.
  • Lentiginous melanoma, a recently defined histologic pattern, represents a slowly progressing melanoma variant.

Purpose of the Study:

  • To review the clinical and histologic features of lentiginous melanoma.
  • To discuss the histologic differential diagnosis of lentiginous melanoma.

Main Methods:

  • Literature review of pertinent published studies.
  • Analysis of laboratory work related to lentiginous melanoma.

Main Results:

  • Lentiginous melanoma is characterized by a broad atypical lentiginous growth pattern with moderately atypical melanocytes.
  • Histologic features include focal nesting, pagetoid spread, and absence of significant dermal fibroplasia or rete ridge alteration.
  • Significant overlap exists between lentiginous melanoma and atypical lentiginous nevus.

Conclusions:

  • Lentiginous melanoma is a distinct subset of slow-progressing melanoma in middle-aged and older patients.
  • Further investigation is needed to clarify the relationship between lentiginous melanoma and atypical lentiginous nevus.
  • Adequately wide excision is recommended for all lesions exhibiting lentiginous melanoma features due to progression risk.