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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

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Related Experiment Video

Updated: Jun 4, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Melanoma prevention using topical PBISe.

Chin-Ying Chung1, SubbaRao V Madhunapantula, Dhimant Desai

  • 1Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, 17033, USA.

Cancer Prevention Research (Philadelphia, Pa.)
|March 4, 2011
PubMed
Summary
This summary is machine-generated.

A new compound, PBISe, shows promise in preventing melanoma development by targeting key signaling pathways. Topical application significantly reduced melanocytic lesion growth in skin models, offering a potential new strategy for skin cancer prevention.

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Area of Science:

  • Oncology
  • Dermatology
  • Molecular Biology

Background:

  • Malignant melanoma is a deadly skin cancer with high metastatic potential and drug resistance.
  • Deregulated PI3 and mitogen-activated protein (MAP) kinase pathways are implicated in melanoma development and drug resistance.
  • Current treatments lack agents to prevent the progression of melanocytic lesions to invasive melanoma.

Purpose of the Study:

  • To investigate the potential of a novel selenium-containing compound, PBISe, in preventing melanoma development.
  • To determine if PBISe can moderate the PI3 and MAP kinase pathways involved in melanocytic lesion progression.

Main Methods:

  • A selenium-containing isosteric analogue, PBISe, was synthesized and tested.
  • Topical application of PBISe on laboratory-generated skin and animal skin models.
  • Analysis of signaling pathway modulation, cell proliferation, and apoptotic cell death.

Main Results:

  • Topical PBISe application retarded melanocytic lesion development by 70-80% in lab-generated skin and approximately 50% in animal skin.
  • PBISe decreased Akt3 signaling, leading to increased inhibitory MAP kinase pathway activity.
  • The combined pathway modulation resulted in reduced cell proliferation and increased apoptosis.

Conclusions:

  • Topically applied PBISe effectively prevents the development of cutaneous melanocytic lesions and invasive melanoma.
  • PBISe moderates key signaling pathways, offering a potential therapeutic strategy for melanoma prevention.
  • This study highlights PBISe as a promising agent for preventing skin cancer progression.