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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
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Helicobacter pylori infection in pediatric candidates for kidney transplantation
Nakysa Hooman1, Mitra Mehrazma, Elham Talachian
1Department of Pediatric Nephrology, Tehran University of Medical Sciences, Tehran, Iran. nakih@hotmail.com
Insights
Helicobacter pylori infection is common in children with end-stage renal disease, particularly older children. Many infected children are asymptomatic but show abnormal endoscopy and gastritis.
Area of Science:
- Pediatric Nephrology
- Gastroenterology
- Infectious Diseases
Background:
- Limited data exists on Helicobacter pylori infection in children with chronic kidney failure.
- Previous studies suggested a protective effect in adults, but this remains unconfirmed in pediatric populations.
Purpose of the Study:
- To determine the prevalence of Helicobacter pylori infection in children with end-stage renal disease.
- To investigate associated endoscopic and histopathological findings.
- To explore correlations with patient demographics and clinical status.
Main Methods:
- Retrospective analysis of 117 children (aged 5-18) undergoing upper gastrointestinal endoscopy before kidney transplantation.
- Gastric antrum specimens were stained using hematoxylin-eosin and Giemsa for Helicobacter pylori detection.
Main Results:
- Helicobacter pylori was detected in 24% of pediatric patients.
- Infection prevalence was higher in children with abnormal endoscopic findings (P = .02).
- Significant correlations were found with histopathological features (P = .005), age over 10 years (P = .003), and endoscopic findings (P = .001).
Conclusions:
- Helicobacter pylori infection is highly prevalent in children with end-stage renal disease, especially older children.
- Most infected children were asymptomatic but exhibited abnormal endoscopic and histopathological findings.
- Findings suggest a need for increased awareness of H. pylori in this pediatric population.
Introduction:
Chronic kidney failure was suggested to have a protective effect against Helicobacter pylori infection in adults. However, data about this effect in children is lacking. This study was designed to ascertain the prevalence, endoscopic findings, and histopathological features accompanying the Helicobacter pylori infection in children with end-stage renal disease.
Materials And Methods:
Data were collected from 117 children with end-stage renal disease aged 5 to 18 years that underwent routine upper gastrointestinal endoscopy before kidney transplantation between 1998 and 2009. The specimens that were taken from the antrum were stained with hematoxylin-eosin and Giemsa to detect Helicobacter pylori.
Results:
Gastrointestinal symptoms were reported in 12% of the patients. Helicobacter pylori was detected in 24% of the children. The prevalence of Helicobacter pylori infection was high in children with abnormal endoscopic findings (P = .02). There was no correlation between Helicobacter pylori infection and gender, dialysis status, duration of dialysis, underlying diseases, and gastrointestinal symptoms. Helicobacter pylori infection had a significant correlation with histopathological features (P = .005), age older than 10 years (P = .003), and upper gastrointestinal endoscopic findings (P = .001).
Conclusions:
In this study, Helicobacter pylori infection had a high prevalence in children with end-stage renal disease, especially in older ones. The majority of children with Helicobacter pylori infection were asymptomatic, while they had abnormal findings on upper gastrointestinal endoscopy and chronic active gastritis features in histopathological assessment.
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