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Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Molecular Pharming: future targets and aspirations.

Mathew Paul1, Craig van Dolleweerd, Pascal M W Drake

  • 1Molecular Immunology Unit, Research Centre for Infection and Immunity, St. George's Hospital Medical School, London, UK.

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|March 4, 2011
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Summary

Molecular pharming offers a chance to produce affordable medicines globally, especially for infectious diseases in developing nations. Research focuses on simple, transferable production strategies for conditions like HIV, TB, and rabies.

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Area of Science:

  • Biotechnology
  • Pharmaceutical Sciences
  • Global Health

Background:

  • Molecular pharming presents a novel approach for large-scale, cost-effective pharmaceutical production.
  • Significant disparities exist in global access to essential medicines and vaccines, particularly in underdeveloped regions.
  • Infectious diseases like HIV, tuberculosis (TB), and rabies disproportionately affect populations with limited healthcare resources.

Purpose of the Study:

  • To explore the potential of molecular pharming for manufacturing affordable medicines.
  • To focus research on developing simple and transferable production strategies for key infectious diseases.
  • To address the critical need for accessible medical interventions in developing countries.

Main Methods:

  • Utilizing plant-based systems for the production of therapeutic proteins and vaccines.
  • Developing scalable and robust manufacturing processes amenable to resource-limited settings.
  • Focusing on diseases with high global impact and limited treatment accessibility.

Main Results:

  • Demonstrated the feasibility of producing affordable medicines through molecular pharming.
  • Identified key challenges and opportunities for technology transfer to developing countries.
  • Established a research focus on HIV, TB, and rabies, with potential for broader applications.

Conclusions:

  • Molecular pharming holds significant promise for improving global health equity.
  • Simple, transferable production strategies are crucial for making modern medicines accessible worldwide.
  • Continued research and development are essential to realize the full potential of molecular pharming for disease prevention and treatment.