A novel metered dose transdermal spray formulation for oxybutynin

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems

Background:

• Oxybutynin is commonly used for treating overactive bladder.
• Transdermal drug delivery offers potential advantages over oral administration, such as reduced side effects and improved patient compliance.

Purpose of the Study:

• To develop and characterize a metered dose spray formulation for transdermal oxybutynin delivery.
• To evaluate the in vitro performance and stability of the optimized spray formulation.

Main Methods:

• Formulation development using various solvents and film-forming agents (Carbopol, Lutrol).
• In vitro characterization including spray pattern, particle size, pH, evaporation time, and drug release studies.
• Stability testing according to ICH guidelines and skin irritation studies in rabbits.

Main Results:

• An optimized formulation using Carbopol (0.5%) and Lutrol (0.1%) exhibited desirable properties like clarity, evaporation rate, and spray pattern.
• In vitro diffusion studies showed approximately 50% drug release over 24 hours.
• The formulation was found to be stable and non-irritating in preliminary animal studies.

Conclusions:

• The developed metered dose transdermal spray is a promising and innovative system for oxybutynin administration.
• This formulation could offer an effective alternative for managing conditions requiring oxybutynin therapy.