Antiinflammatory activity of a polyherbal formulation

Area of Science:

• Pharmacology
• Natural Product Research
• Inflammation Studies

Background:

• Inflammation is a complex biological response implicated in various diseases.
• Natural products are increasingly explored for therapeutic anti-inflammatory properties.
• Entox is a polyherbal formulation with potential therapeutic applications.

Purpose of the Study:

• To investigate the anti-inflammatory activity of the polyherbal formulation Entox(®).
• To evaluate Entox(®) in established acute and sub-acute inflammation models in rats.

Main Methods:

• Carrageenan-induced rat paw edema model for acute inflammation.
• Cotton pellet granuloma method for sub-acute inflammation.
• Oral administration of Entox(®) at doses of 300 mg/kg and 600 mg/kg.

Main Results:

• Entox(®) significantly inhibited carrageenan-induced paw edema by 51.61% (300 mg/kg) and 54.84% (600 mg/kg) at 3 hours.
• The formulation reduced cotton pellet granuloma by 27.92% (300 mg/kg) and 53.17% (600 mg/kg).
• Anti-inflammatory activity was comparable to the standard drug, indomethacin.

Conclusions:

• Entox(®) exhibits significant anti-inflammatory activity in both acute and sub-acute experimental models.
• The findings support the potential of Entox(®) as a therapeutic agent for inflammatory conditions.
• Further research into the specific active compounds and mechanisms of Entox(®) is warranted.