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Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles
Published on: August 26, 2018
Pharmacological potential of cerium oxide nanoparticles
Ivana Celardo1, Jens Z Pedersen, Enrico Traversa
1Dipartimento di Biologia, Università di Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133, Rome, Italy.
Nanoscale
|March 4, 2011
Summary
Cerium oxide nanoparticles (nanoceria) exhibit potent antioxidant properties, mimicking key enzymes to combat harmful reactive oxygen species (ROS). This review explores their potential in treating oxidative stress-related diseases like cancer and neurodegeneration.
Area of Science:
- Nanomedicine
- Pharmacology
- Materials Science
Background:
- Nanotechnology offers novel therapeutic strategies in pharmacology.
- Cerium oxide nanoparticles (nanoceria) possess unique catalytic and antioxidant properties.
- The pharmacological potential of nanoceria stems from Ce(3+) ions and oxygen vacancies.
Purpose of the Study:
- To review the biological effects of nanoceria.
- To explore their antioxidant mechanisms and biocompatibility.
- To assess their therapeutic potential against oxidative stress-related diseases.
Main Methods:
- In vitro studies on nanoceria's biological effects.
- In vivo studies evaluating nanoceria's efficacy and safety.
- Analysis of nanoceria's antioxidant enzyme-mimicking capabilities.
Main Results:
- Nanoceria effectively scavenge reactive oxygen species (ROS) via self-regenerating redox cycles.
- They mimic superoxide dismutase and catalase enzymes.
- Studies indicate good biocompatibility and potential to mitigate oxidative stress.
Conclusions:
- Nanoceria demonstrate significant therapeutic promise due to their antioxidant activity.
- They may offer novel treatments for chronic inflammation, cancer, and neurodegenerative diseases.
- Further research into nanoceria's biological effects is warranted.
