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Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Reticular Dermis

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: Jun 4, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

[Registry research in dermatology].

S J Rustenbach¹, K Heyer, K Reppenhagen

¹Competenzzentrum Versorgungsforschung in der Dermatologie, Institut für Versorgungsforschung in der Dermatologie und bei Pflegeberufen, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg. s.rustenbach@uke.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|March 4, 2011

Summary

This summary is machine-generated.

Patient registries systematically collect observational health data reflecting real-world practices. These valuable resources are crucial for evaluating long-term outcomes and improving healthcare efficiency.

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Area of Science:

Health Services Research
Clinical Medicine
Observational Studies

Context:

Patient registries are prospective, systematic, non-interventional data collections.
They capture routine care practices, including common disease characteristics and medical interventions.
The significance of registries in health services research and clinical medicine is growing due to resource constraints and the need for evidence on benefits and efficiency.

Purpose:

To provide an overview of patient registry methodology, from definitions to data analysis.
To summarize existing registries within the field of dermatology in Germany.
To highlight the increasing importance and utility of registries in modern healthcare.

Summary:

Registries offer insights into long-term outcomes such as quality of life, treatment effectiveness, and quality of care.
They are essential for evaluating interventions under real-world conditions.
The study details registry methodology and presents a summary of German dermatology registries.

Impact:

Enhances understanding of patient registry methodology and application.
Facilitates research by summarizing existing dermatology registries in Germany.
Supports evidence-based healthcare by demonstrating the value of real-world data for outcome evaluation.