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Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Detection of microsatellite instability.

K D Berg¹, C A Griffin, J R Eshleman

¹Department of Pathology, Johns Hopkim School of Medicine, Baltimore, MD.

Methods in Molecular Medicine

|March 4, 2011

Summary

This summary is machine-generated.

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Tumor microsatellite lengths can change, a phenomenon known as microsatellite instability (MSI) or replication errors (RER). This instability involves alterations in repetitive DNA sequences compared to normal tissue.

Area of Science:

Genetics
Oncology

Background:

Microsatellites are repetitive DNA sequences with varying lengths.
In 1993, researchers discovered microsatellite length alterations in tumors.
This phenomenon is termed microsatellite instability (MSI) or replication errors (RER).

Purpose of the Study:

To define microsatellite instability (MSI) or replication errors (RER).

Main Methods:

The study references the discovery of microsatellite length variations in tumors.
It cites an international consensus conference defining MSI/RER.
It describes microsatellites as repetitive DNA regions (1-6 nucleotide units).

Main Results:

Microsatellite lengths in tumors can differ from the germline pattern.

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Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

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MSI/RER is defined as a tumor microsatellite length change compared to normal tissue.

Microsatellite length variations are utilized in forensics and gene mapping.

Conclusions:

Microsatellite instability is a key characteristic of some tumors.
Understanding MSI/RER aids in cancer research and diagnostics.